dear sir,my mom is having rashes n anflamation all overthe skin of body due to the intake of drug {aceclofenac 100 mg, paracetamol 500 mg} named DOLOKIND PLUS...please suggest me some remedy for this reaction..

I am sorry to hear that your mom is experiencing these unpleasant reactions. It may or may not be related to her use of aceclofenac/paracetamol, though it is entirely possible that this medication is the culprit.

Generally there is no 100% surefire way to determine if a drug is causing a reaction but there are certain things pharmacists and doctors look for that increase the liklihood that the medication is involved in a particular reaction.

The most important thing is timing. When did your mom take the medication and when did the reaction occur? Was it within 15 minutes, one hour, one day, one week? Has she ever had a reaction like this before? Has she taken this same medication before without this reaction?

Another thing to consider would be whether other things may have changed in you mom's daily life. Has she started using a new detergent? Does she have a new job or new living situation which exposes her to a new environment?

Since it is impossible for me to determine if your mom is reacting to this medication, let's assume that she is for the purpopses of this discussion.

She could be reacting to the aceclofenac, a non-steroidal anti-inflammatory drug (NSAID). Aceclofenac and other NSAID's have been associated with a 0.1% to 1% risk of pruritis, rash, eczema, dermatits, and urticaria. In very rare situations, they have also been associated with epidermal necrolysis, erythema multiforme, and exfoliative dermatits.

She could instead be reacting to an inactive ingredient in the tablet. Some people can be sensitive to dyes or excipients in a drug formulation. In particular, this medication may contain povidone, a form of iodine. If your mom is allergic to iodine, she could be reacting to this.

Finally, you mention that the medication your mom took contains paracetamol. Does she take any other medications that contain paracetamol, or does she take extra paracetamol tablets regularly? Does she have any history of liver disease? Does she drink alcohol? The reason I ask is because paracetamol can be toxic to the liver in doses greater than 4 grams daily or if taken in combination with regular alcohol use. Paracetamol can cause liver damage which then can affect proper blood clotting. If this happens, a person can bleed under the skin in a particular pattern called petechiae which appears as small, widespread dots and could be mistaken for a rash.

Allergic dermatological reactions such as hives, rash, and eczema from paracetamol are quite rare but possible.

If your mother has petechiae or if any of her skin sloughs off, these are signs of a medical emergency which requires urgent medical attention.

If you have consulted with a healthcare professional who ruled out serious and dangerous reactions and it is determined that your mother is simply having an allergic reaction, this is usually treated by discontinuing the offending medication and time. Anti-inflammatory medications and creams may be used and could include hydrocortisone, diphenhydramine, hydroxyzine, or oral or topical steroids such as prednisone, triamcinolone,and clobetasol.