According to a study in the Journal of the National Cancer Institute, the combination of folic acid, vitamin B6 and vitamin B12 has no effect on reducing the risk of developing colorectal adenoma a precursor to colorectal cancer.
This runs counter to prior pre-clinical and epidemiological studies that suggested that folate and B vitamins had some effect against the disease.
Seeking to determine the possible effects of folic acid, vitamin B6 and vitamin B12 on the risk of colorectal adenoma, Yiqing Song, M.D., of Harvard Medical School and colleagues carried out a retroprospective study in the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS).
WAFACS was a randomized, double-blind, placebo-controlled trial with 5,442 female health professionals at high risk for cardiovascular disease. It took place between April 1998 and July 2005.
WAFACS participants were randomly assigned to:
1. A combination of folic acid, vitamin B6 and vitamin B12
Saying that more research was needed to confirm their study, the researchers none the less wrote that their findings "do not support recommending B-vitamin supplementation for the prevention of colorectal adenomas."
Source: Medical News Today